The HFC phase-down measures and its implementation through EU and non-EU F-gas regulations, settle the direction for next generation refrigerants in the comfort cooling and heating market. Or do they? Recent product announcements show opportunities in the use of natural refrigerants, but still today there is no one-refrigerant-fits-all solution. Further study is ongoing, as an optimal balance must be found in supporting all market applications, in a safe and affordable way. What can manufacturers, installers and end-users expect? An outlook on refrigerant alternatives on the short-to-medium term.