Updated European F-Gas regulation in place to mitigate climate change, are going to limit further the usage of high GWP refrigerants in the next few years in the majority of categories of refrigeration and air conditioning applications. Except CO2 most of known alternatives with low GWP, are flammable in some extent. In recent years, intense activity on existing safety standards update took place and the other updates are still in progress. This presentation will summarize the present status of international and regional product standards for commercial refrigeration and describe gaps still to be covered for full implementation of the new F-Gas regulation.